Reyataz is an HIV medication. It is in a category of HIV medicines called protease inhibitors (PIs). Reyataz prevents cells infected with HIV from producing new virus. This reduces the amount of virus in your body.
Reyataz must be used in combination with at least two other HIV drugs.
Reyataz is broken down (metabolized) by the liver, like many medications used to treat HIV and AIDS. This means that Reyataz can interact with other medications. Reyataz can lower or raise the levels of other medications in the body. Similarly, other medications can lower or raise the levels of Reyataz in the body. While many interactions are not a problem, some can cause your medications to be less effective or increase the risk of side effects.
The following medications should not be taken while you are being treated with Reyataz:
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HIV protease inhibitors: Crixivan (indinavir)
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Acid reflux/heartburn medications: Propulsid (cisapride)
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Antibiotics: Rifadin (rifampin)
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Cancer chemotherapeutics: Camptosar (irinotecan)
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Antimigraine medications: Methergine, Methylergometrine (methylergonovine); Ergostat, Cafergot, Ercaf, Wigraine (ergotamine); Ergotrate, Methergine (ergonovine); or D.H.E. 45, Migranal (dihydroergotamine)
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Antihistamines: Hismanal (astemizole) or Seldane (terfenadine)
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Steroids: Flonase of Flovent (fluticasone)
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Cholesterol-lowering drugs (statins): Zocor (simvastatin) and Mevacor (lovastatin)
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Antipsychotics: Orap (pimozide)
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Sedatives: Versed (midazolam) and Halcion (triazolam)
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Herbal medications: St. John's wort
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Enlarged prostate: Uroxatral (alfuzosin)
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Pulmonary Hypertension: sildenafil, used as Revatio
If Reyataz is combined with low-dose Norvir, the following medications should also be avoided:
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Antifungals: Vfend (voriconazole)
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Heart medications: Cordarone (amiodarone), Tambocor (flecainide), Vascor (bepridil), Rythmol (propafenone), or Quinaglute/Quinidex (quinidine)
Anticonvulsants, such as Tegretol (carbamazepine), Luminal (phenobarbital), and Dilantin (phenytoin), may decrease the amount of Reyataz in the bloodstream. It might be necessary to increase your dose of Reyataz if you are taking any of these drugs.
Caution is needed when combining Reyataz with proton pump inhibitors (PPI) --used to treat heartburn and acid reflux--examples of which include include Propulsid (cisaprid), Nexium (esomeprazole), Prevacid (lansoprazole), Prilosec (omeprazole) and Protonix (pantoprazole). This is because Reyataz requires stomach acid to be absorbed properly by the body. Because PPIs greatly reduce stomach acid, they can decrease the amount of Reyataz that gets absorbed into the blood stream.
For HIV-positive people new to HIV treatment using 300mg Reyataz combined with 100mg Norvir, PPIs must be taken 12 hours before taking Reyataz, and the PPI dose must not exceed the equivalent of 20mg of Prilosec.
Reyataz can increase levels of bilirubin, a pigment found in the liver. Increased bilirubin can cause the skin, nails, and the whites of the eyes to appear yellowish-brown. Increased bilirubin can also be a sign of liver damage. However, in people who have taken Reyataz in clinical trials, an increase in bilirubin has not been associated with any other signs of liver damage. Reyataz should not be combined with Crixivan, another protease inhibitor that can cause increased bilirubin levels.
There have been reports of patients developing painful kidney stones while on HIV drug regimens containing Reyataz. While little is known about the frequency of the kidney stones, or if certain risk factors are involved, increasing fluid intake while taking Reyataz may help decrease the risk of this possible side effect.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
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