Atripla is an HIV medication. It contains two different types of HIV drugs: one non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs).
Atripla is a combination of three drugs: 600 mg of Sustiva (efavirenz), 300mg of Viread (tenofovir DF) and 200mg of Emtriva (emtricitabine). Atripla should be prescribed by a healthcare provider for patients who need all three of these drugs. All three drugs can still be purchased individually for use in combination with other HIV drugs.
Atripla is considered to be a complete one-pill, once-daily HIV treatment regimen. Atripla can be used alone or with other antiretrovirals if needed.
The following medications should not be taken while you are being treated with Atripla:
Antifungals: Vfend (voriconazole)
Antipsychotics: Orap (pimozide)
Acid reflux/heartburn medications: Propulsid (cisapride)
Heart medications: Vascor (bepridil)
Sedatives: Versed (midazolam) and Halcion (triazolam)
Antimigraine medications: Wigraine and Cafergot (ergot medications).
Herbal products: St. John's wort (or products containing St. John's wort.
Atripla should not be taken at the same time as Sustiva, Emtriva, Viread, Hepsera, Truvada (tenofovir plus emtricitabine), Epivir (lamivudine) or other combination tablets that contain Epivir (for example, Epzicom, Combivir or Trizivir). This is because these medications contain the same or similar active ingredients as Atripla.
Many patients have dizziness, headache, trouble sleeping, drowsiness, trouble concentrating, and/or unusual dreams after starting treatment with Atripla. These feeling may be less noticeable if you take Atripla at bedtime on an empty stomach. They also tend to go away after you've taken the medicine for a few weeks. If you have these side effects, such as dizziness, it does not mean that you will also have severe depression, strange thoughts or angry behavior. Tell your doctor promptly if any of these side effects continue or if they bother you. There is the possibility that these symptoms may be more severe if Atripla is used with alcohol or mood-altering (street) drugs. You should also avoid driving or operating machinery if you are having these side effects. Check out our lesson on Tips & Tricks on Taking Sustiva to learn more.
A small number of patients have had severe depression, strange thoughts, or angry behavior while taking Sustiva, one of the drugs in Atripla. Some patients have had thoughts of suicide and a few patients have actually committed suicide. These problems tend to occur more often in patients with a history of mental illness. You should contact your doctor immediately if you think you are having these symptoms, so your doctor can decide whether you should continue to take Sustiva.